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Videnskabelige artikler

Publikationer fra Odense Børnekohorte, den nyeste står øverst.

43. Bruun, S., L. van Rossem, L. Lauritzen, S. Husby, L. Neergaard Jacobsen, K. F. Michaelsen, M. Boysen Sandberg, K. D. Stark, J. Sorensen, and G. Zachariassen. "Content of N-3 Lc-Pufa in Breast Milk Four Months Postpartum Is Associated with Infancy Blood Pressure in Boys and Infancy Blood Lipid Profile in Girls." Nutrients 11, no. 2 (Jan 22 2019). http://dx.doi.org/10.3390/nu11020235.


42. Jensen RC, Glintborg D, Timmermann CAG, Nielsen F, Kyhl HB, Andersen HR, et al. Perfluoroalkyl substances and glycemic status in pregnant Danish women: The Odense Child Cohort. Environment international. 2018;116:101-7. http://dx.doi.org/10.1016/j.envint.2018.04.010.


41. Bruun, S., S. Gouveia-Figueira, M. Domellof, S. Husby, L. Neergaard Jacobsen, K. F. Michaelsen, C. J. Fowler, and G. Zachariassen. "Satiety Factors Oleoylethanolamide, Stearoylethanolamide, and Palmitoylethanolamide in Mother's Milk Are Strongly Associated with Infant Weight at Four Months of Age-Data from the Odense Child Cohort." Nutrients 10, no. 11 (Nov 13 2018). http://dx.doi.org/10.3390/nu10111747.

 40. Larsen, S. D., C. Dalgard, M. E. Christensen, S. Lykkedegn, L. B. Andersen, M. Andersen, D. Glintborg, and H. T. Christesen. "Blood Pressure in 3-Year-Old Girls Associates Inversely with Umbilical Cord Serum 25-Hydroxyvitamin D." Endocr Connect  (Oct 1 2018). https://www.ncbi.nlm.nih.gov/pubmed/30352408

 39. Palm CVB, Glintborg D, Kyhl HB, McIntyre HD, Jensen RC, Jensen TK, et al. Polycystic ovary syndrome and hyperglycaemia in pregnancy. A narrative review and results from a prospective Danish cohort study. Diabetes research and clinical practice. 2018. http://dx.doi.org/10.1016/j.diabres.2018.04.030

 38. Olesen TS, Bleses D, Andersen HR, Grandjean P, Frederiksen H, Trecca F, et al. Prenatal phthalate exposure and language development in toddlers from the Odense Child Cohort. Neurotoxicology and teratology. 2018;65:34-41. http://dx.doi.org/10.1016/j.ntt.2017.11.004

 37. McIntyre HD, Jensen DM, Jensen RC, Kyhl HB, Jensen TK, Glintborg D, et al. Gestational Diabetes Mellitus: Does One Size Fit All? A Challenge to Uniform Worldwide Diagnostic Thresholds. Diabetes care. 2018;41(7):1339-42. http://dx.doi.org/10.2337/dc17-2393.

 36. Glintborg D, Jensen RC, Bentsen K, Schmedes AV, Brandslund I, Kyhl HB, et al. Testosterone levels in 3rd trimester in polycystic ovary syndrome. Odense Child Cohort. The Journal of clinical endocrinology and metabolism. 2018. http://dx.doi.org/10.1210/jc.2018-00889

 35. Dalsager L, Christensen LE, Kongsholm MG, Kyhl HB, Nielsen F, Schoeters G, et al. Associations of maternal exposure to organophosphate and pyrethroid insecticides and the herbicide 2,4-D with birth outcomes and anogenital distance at 3 months in the Odense Child Cohort. Reproductive toxicology (Elmsford, NY). 2018;76:53-62. http://dx.doi.org/10.1016/j.reprotox.2017.12.008

 34. Christensen ME, Beck-Nielsen SS, Dalgard C, Larsen SD, Lykkedegn S, Kyhl HB, et al. A novel inverse association between cord 25-hydroxyvitamin D and leg length in boys up to three years. An Odense Child Cohort study. PloS one. 2018;13(6):e0198724. http://dx.doi.org/10.1371/journal.pone.0198724

 33. Bruun S, Jacobsen LN, Ze X, Husby S, Ueno HM, Nojiri K, et al. Osteopontin Levels in Human Milk Vary Across Countries and Within Lactation Period: Data From a Multicenter Study. Journal of Pediatric Gastroenterology and Nutrition. 2018;67(2):250-6. http://dx.doi.org/10.1097/mpg.0000000000002004

 32. Baekgaard Thorsen LH, Bjorkholt Andersen L, Birukov A, Lykkedegn S, Dechend R, Stener Jorgensen J, et al. Prediction of birth weight small for gestational age with and without preeclampsia by angiogenic markers: An Odense Child Cohort study. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet. 2018:1-201. http://dx.doi.org/10.1080/14767058.2018.1519536

 31. Al-Jwadi RF, Jespersen E, Dalgard C, Bilenberg N, Christesen HT. S-25OHD Is Associated With Hand Grip Strength and Myopathy at 5 Years in Girls: An Odense Child Cohort Study. The Journal of clinical endocrinology and metabolism. 2018;103(7):2630-9. http://dx.doi.org/10.1210/jc.2018-00281

 30. Priskorn L, Petersen JH, Jorgensen N, Kyhl HB, Andersen MS, Main KM, et al. Anogenital distance as a phenotypic signature through infancy. Pediatric research. 2017. http://dx.doi.org/10.1038/pr.2017.287

 29. Mydtskov ND, Lykkedegn S, Fruekilde PBN, Nielsen J, Barington T, Christesen HT. S-25-hydroxyvitamin D and C3-epimers in pregnancy and infancy: An Odense Child Cohort study. Clinical biochemistry. 2017;50(18):988-96. http://dx.doi.org/10.1016/j.clinbiochem.2017.07.001

 28. Mossin MH, Aaby JB, Dalgard C, Lykkedegn S, Christesen HT, Bilenberg N. Inverse associations between cord vitamin D and attention deficit hyperactivity disorder symptoms: A child cohort study. The Australian and New Zealand journal of psychiatry. 2017;51(7):703-10. http://dx.doi.org/10.1177/0004867416670013

 27. Mogensen DM, Pihl MB, Skakkebaek NE, Andersen HR, Juul A, Kyhl HB, et al. Prenatal exposure to antifungal medication may change anogenital distance in male offspring: a preliminary study. Environmental health : a global access science source. 2017;16(1):68. http://dx.doi.org/10.1186/s12940-017-0263-z

 26. Lykkedegn S, Beck-Nielsen SS, Sorensen GL, Andersen LB, Fruekilde PBN, Nielsen J, et al. Vitamin D supplementation, cord 25-hydroxyvitamin D and birth weight: Findings from the Odense Child Cohort. Clinical nutrition (Edinburgh, Scotland). 2017;36(6):1621-7. http://dx.doi.org/10.1016/j.clnu.2016.10.008

 25. Lind DV, Priskorn L, Lassen TH, Nielsen F, Kyhl HB, Kristensen DM, et al. Prenatal exposure to perfluoroalkyl substances and anogenital distance at 3 months of age in a Danish mother-child cohort. Reproductive toxicology (Elmsford, NY). 2017;68:200-6. http://dx.doi.org/10.1016/j.reprotox.2016.08.019

 24. Lind DV, Main KM, Kyhl HB, Kristensen DM, Toppari J, Andersen HR, et al. Maternal use of mild analgesics during pregnancy associated with reduced anogenital distance in sons: a cohort study of 1027 mother-child pairs. Human reproduction (Oxford, England). 2017;32(1):223-31. http://dx.doi.org/10.1093/humrep/dew285

 23. Finnbogadottir SK, Glintborg D, Jensen TK, Kyhl HB, Nohr EA, Andersen M. Insulin resistance in pregnant women with and without polycystic ovary syndrome, and measures of body composition in offspring at birth and three years of age. Acta obstetricia et gynecologica Scandinavica. 2017;96(11):1307-14. http://dx.doi.org/10.1111/aogs.13200

 22. Egge S, Christensen N, Lykkedegn S, Jensen TK, Christesen HT. Cord serum 25-hydroxyvitamin D is not associated with cranial anthropometrics in infants up to 6 months of age. An Odense Child Cohort study. Journal of bone and mineral metabolism. 2017. http://dx.doi.org/10.1007/s00774-017-0881-0

 21. Christensen N, Sondergaard J, Fisker N, Christesen HT. Infant Respiratory Tract Infections or Wheeze and Maternal Vitamin D in Pregnancy: A Systematic Review. The Pediatric infectious disease journal. 2017;36(4):384-91. http://dx.doi.org/10.1097/inf.0000000000001452

 20. Christensen N, Sondergaard J, Christesen HT, Fisker N, Husby S. Association Between Mode of Delivery and Risk of Infection in Early Childhood: A Cohort Study. The Pediatric infectious disease journal. 2017. http://dx.doi.org/10.1097/inf.0000000000001778

 19. Bruun S, Buhl S, Husby S, Jacobsen LN, Michaelsen KF, Sorensen J, et al. Breastfeeding, Infant Formula, and Introduction to Complementary Foods-Comparing Data Obtained by Questionnaires and Health Visitors' Reports to Weekly Short Message Service Text Messages. Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine. 2017;12(9):554-60. http://dx.doi.org/10.1089/bfm.2017.0054

 18. Luef BM, Andersen LB, Renault KM, Nohr EA, Jorgensen JS, Christesen HT. Validation of hospital discharge diagnoses for hypertensive disorders of pregnancy. Acta obstetricia et gynecologica Scandinavica. 2016;95(11):1288-94. http://dx.doi.org/10.1111/aogs.13006

 17. Lassen TH, Frederiksen H, Kyhl HB, Swan SH, Main KM, Andersson AM, et al. Prenatal Triclosan Exposure and Anthropometric Measures Including Anogenital Distance in Danish Infants. Environmental health perspectives. 2016;124(8):1261-8. http://dx.doi.org/10.1289/ehp.1409637

 16. Larnkjaer A, Bruun S, Pedersen D, Zachariassen G, Barkholt V, Agostoni C, et al. Free Amino Acids in Human Milk and Associations With Maternal Anthropometry and Infant Growth. Journal of pediatric gastroenterology and nutrition. 2016;63(3):374-8. http://dx.doi.org/10.1097/mpg.0000000000001195

 15. Jensen TK, Frederiksen H, Kyhl HB, Lassen TH, Swan SH, Bornehag CG, et al. Prenatal Exposure to Phthalates and Anogenital Distance in Male Infants from a Low-Exposed Danish Cohort (2010-2012). Environmental health perspectives. 2016;124(7):1107-13. http://dx.doi.org/10.1289/ehp.1509870

 14. Dalsager L, Christensen N, Husby S, Kyhl H, Nielsen F, Host A, et al. Association between prenatal exposure to perfluorinated compounds and symptoms of infections at age 1-4years among 359 children in the Odense Child Cohort. Environment international. 2016;96:58-64. http://dx.doi.org/10.1016/j.envint.2016.08.026

 13. Bruun S, Wedderkopp N, Molgaard C, Kyhl HB, Zachariassen G, Husby S. Using text messaging to obtain weekly data on infant feeding in a Danish birth cohort resulted in high participation rates. Acta paediatrica (Oslo, Norway : 1992). 2016;105(6):648-54. http://dx.doi.org/10.1111/apa.13382

 12. Andersen LB, Jorgensen JS, Herse F, Andersen MS, Christesen HT, Dechend R. The association between angiogenic markers and fetal sex: Implications for preeclampsia research. Journal of reproductive immunology. 2016;117:24-9. http://dx.doi.org/10.1016/j.jri.2016.05.005

 11. Andersen LB, Dechend R, Karumanchi SA, Nielsen J, Joergensen JS, Jensen TK, et al. Early pregnancy angiogenic markers and spontaneous abortion: an Odense Child Cohort study. American journal of obstetrics and gynecology. 2016;215(5):594.e1-.e11. http://dx.doi.org/10.1016/j.ajog.2016.06.007

 10. Andersen LB, Dechend R, Jorgensen JS, Luef BM, Nielsen J, Barington T, et al. Prediction of preeclampsia with angiogenic biomarkers. Results from the prospective Odense Child Cohort. Hypertension in pregnancy. 2016;35(3):405-19. http://dx.doi.org/10.3109/10641955.2016.1167219

 9. Kyhl HB, Jensen TK, Barington T, Buhl S, Norberg LA, Jorgensen JS, et al. The Odense Child Cohort: aims, design, and cohort profile. Paediatric and perinatal epidemiology. 2015;29(3):250-8. http://dx.doi.org/10.1111/ppe.12183

 8. Jensen TK, Andersen LB, Kyhl HB, Nielsen F, Christesen HT, Grandjean P. Association between perfluorinated compound exposure and miscarriage in Danish pregnant women. PloS one. 2015;10(4):e0123496. http://dx.doi.org/10.1371/journal.pone.0123496

 7. Andersen LB, Jorgensen JS, Jensen TK, Dalgard C, Barington T, Nielsen J, et al. Vitamin D insufficiency is associated with increased risk of first-trimester miscarriage in the Odense Child Cohort. The American journal of clinical nutrition. 2015;102(3):633-8. http://dx.doi.org/10.3945/ajcn.114.103655

 6. Andersen LB, Frederiksen-Moller B, Work Havelund K, Dechend R, Jorgensen JS, Jensen BL, et al. Diagnosis of preeclampsia with soluble Fms-like tyrosine kinase 1/placental growth factor ratio: an inter-assay comparison. Journal of the American Society of Hypertension : JASH. 2015;9(2):86-96. http://dx.doi.org/10.1016/j.jash.2014.11.008

 5. Vorkamp K, Nielsen F, Kyhl HB, Husby S, Nielsen LB, Barington T, et al. Polybrominated diphenyl ethers and perfluoroalkyl substances in serum of pregnant women: levels, correlations, and potential health implications. Archives of environmental contamination and toxicology. 2014;67(1):9-20. http://dx.doi.org/10.1007/s00244-013-9988-z

 4. Tefre de Renzy-Martin K, Frederiksen H, Christensen JS, Boye Kyhl H, Andersson AM, Husby S, et al. Current exposure of 200 pregnant Danish women to phthalates, parabens and phenols. Reproduction (Cambridge, England). 2014;147(4):443-53. http://dx.doi.org/10.1530/rep-13-0461

 3. Frederiksen H, Jensen TK, Jorgensen N, Kyhl HB, Husby S, Skakkebaek NE, et al. Human urinary excretion of non-persistent environmental chemicals: an overview of Danish data collected between 2006 and 2012. Reproduction (Cambridge, England). 2014;147(4):555-65. http://dx.doi.org/10.1530/rep-13-0522

 2. Larsen PS, Kamper-Jorgensen M, Adamson A, Barros H, Bonde JP, Brescianini S, et al. Pregnancy and birth cohort resources in europe: a large opportunity for aetiological child health research. Paediatric and perinatal epidemiology. 2013;27(4):393-414. http://dx.doi.org/10.1111/ppe.12060

1. Andersen LB, Abrahamsen B, Dalgard C, Kyhl HB, Beck-Nielsen SS, Frost-Nielsen M, et al. Parity and tanned white skin as novel predictors of vitamin D status in early pregnancy: a population-based cohort study. Clinical endocrinology. 2013;79(3):333-41. http://dx.doi.org/10.1111/cen.12147


Af alle publikationer skal OPEN fremgå som affiliation til mindst en af forfatterne. Dette angives som: ”OPEN, Odense Patient data Explorative Network, Odense University Hospital, Odense, Denmark.”. som: ”OPEN, Odense Patient data Explorative Network, Odense University Hospital, Odense, Denmark.”. Det vil normalt være projektkoordinatoren, men øvrige forskere, som arbejder på projektet, kan ligeledes bruge denne ekstra affiliering. Hvis tidsskriftet tillader det, må man meget gerne inkludere hyperlink til OPEN: www.sdu.dk/ki/open. Hvis en af forfatterne er tilknyttet Syddansk Universitet skal artiklen indberettes med OPEN affiliering i Pure (universitetets indberetningssystem for publikationer). I fald ingen af forfatterne er tilknyttet Syddansk Universitet, skal OPEN via mail til open@rsyd.dk have besked om publicering af artikler med henblik på registrering.


Odense City and Odense University Hospital provides core-funding support for the Odense Child Cohort study. Other contributors are: the Mental Health Service in the Region of Southern Denmark, K.A. Rohde’s and wife’s Foundation, the Ronald McDonald Child Foundation, the Health Insurance Foundation and the Odense University Hospital Research Fund. 


We thank all the families who are part of this study, the Odense Child Cohort co-workers, the midwives for their help in recruitment and collection of samples together with the Biomedical Laboratory Scientist and the assistants, the home nurses/health visitors for their recruitment assistance and the laboratory technicians at the Department of Clinical Biochemistry and Pharmacology, Odense University Hospital.

Hvis det yderligere ønskes at nævne OPEN kan denne tekst benyttes:

This work used the technical facilities of OPEN (Odense Patient data Explorative Network), Odense University Hospital, Odense, Denmark.