Sammenhængen mellem sporstoffer hos gravide og børns kognitive udvikling

The association between maternal copper, selenium, iodide and zinc status during pregnancy and the cognitive development in children until 9 years-of-age: The Odense Child Cohort Study

Purpose?

• To investigate the dynamics during pregnancy of three trace elements, i.e. copper (Cu), selenium (Se) and zinc (Zn), along with protein markers like ceruloplasmin and selenoprotein P, and to compare measurements of these biomarkers assessed by enzyme-linked immunosorbent assay (ELISA) vs. total reflection X-Ray fluorescence (TXRF technology).

• To assess whether the mother’s content of these trace elements, during the 1st and 3rd trimester, respectively, relates to obstetric events, e.g. hypertension in pregnancy and preeclampsia.

• To assess whether the mother’s content of these trace elements, corrected for the iodine status, relates to neurodevelopmental outcomes in the offspring.

• To examine whether the presence of autoantibodies against various epitopes related to trace element status and endocrine factors is associated with obstetric events and offspring development.